FUNCTIONAL ROLE OF N-LINKED GLYCOSYLATION IN HUMAN HEPATIC LIPASE: ASPARAGINE-56 IS IMPORTANT FOR BOTH ENZYME ACTIVITY AND SECRETION.

Functional role of N-linked glycosylation in human hepatic lipase: asparagine-56 is important for both enzyme activity and secretion.

Hepatic lipase (HL) and lipoprotein lipase (LPL) are evolutionarily related enzymes that are essential for normal lipoprotein metabolism.While much has been published on the structure-function relationship of LPL, little is known concerning the structural basis of HL action and secretion.Human HL is a glycoprotein and its predicted amino acid seque

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Spin Qubits Confined to a Silicon Nano-Ridge

Electrostatically-defined quantum dots (QDs) in silicon are an attractive platform for quantum computation.Localized single electron spins define qubits and provide excellent manipulation and read-out fidelities.We propose a scalable silicon-based qubit device that can be fabricated by industry-compatible processes.The device consists of a dense ar

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